| Affiliations: | Michael E. DeBakey Institute Undergraduate Research Program |
| Project Leader: | Ian Stoute imstoute@tamu.edu Biomedical Sciences |
| Faculty Mentor: | Christopher Quick, Ph.D. |
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Meeting Times:
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Summer 2017: TBD |
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Team Size:
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4 (Team Full) |
| Open Spots: | 0 |
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Special Opportunities:
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This project is well-developed, and a manuscript is in the early stages of preparation. Team members will have an opportunity to continue this project in the Fall, and those making a scientific contribution will earn co-authorship. |
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Team Needs:
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We are seeking students who either have an interest in employing their strong writing skills or have an interest in developing an in-depth knowledge of the scientific literature dealing with cardiac function. Understanding of mathematical approaches to physiology are welcome, but unnecessary. Must be willing to work outside of the team meeting time. Contributors must be flexible with their schedules. Students will be expected to register for 3 ch of research (VTPP 291/491 or BMEN 291/491). |
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Description:
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Preload recruitable stroke work (PRSW) is a fundamental characterization of cardiac function that is independent of preload and afterload. It is typically expressed as an empirical relationship between stroke work (SW) and end-diastolic volume (Ved). This relationship has been reported to be remarkably linear over large ranges of end-diastolic volumes in multiple mammalian species. Although the slope and intercept of the PRSW relationship shift significantly with different heart failure phenotypes, there is currently no means to predict in what way changes in contractility, diastolic stiffness, or unstressed volume will affect the PRSW relationship. Therefore, the purpose of the present work was to develop an algebraic formula for the PRSW relationship in terms of standard parameters characterizing systolic and diastolic function. |