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Spring 2021: Effect of renal lymphangiogenesis on Acute Kidney Injury

Affiliations:
Project Leader: Gaurav Baranwal
gauravbaranwal@tamu.edu
Medical Physiology
Faculty Mentor: Dr. Joseph Rutkowski, Ph.D.
Meeting Times:
TBA
Team Size:
4
Open Spots: 0
Special Opportunities:
If contributed significantly, would get co-authorship in publications coming out of the work.
Team Needs:
Key points for project which will help you decide to apply or not would be: 6-8h/week; Involves handling mice (training would be provided but willingness to learn and execute is important).
Description:
Acute kidney injury (AKI) is a major cause of patient mortality and experimental data suggest AKI as an increased risk factor for progression to chronic kidney disease (CKD). The pathological transition from AKI to CKD is not well understood. Not only the degree of the initial AKI inflammatory response, but also how well it resolves – both in time and in function – are likely factors dictating the potential for future CKD progression. Lymphatic vessels and lymphangiogenesis (LAG) are necessary to maintain tissue homeostasis through fluid, macromolecule, and immune cell clearance. Inflammation-associated LAG is necessary for a timely resolution of peripheral inflammation. What roles renal lymphatics play in AKI recovery or CKD progression is largely unknown. The long term goal of the project is to understand the mechanisms by which lymphatic vessels regulate kidney function during AKI and AKI to CKD transition. Team members will be focused on identifying and quantifying the differences in how LAG impacts AKI -to-CKD.

 

Written by:
Elif Kilicarslan
Published on:
November 13, 2020

Categories: FullTags: Spring 2021

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