| Affiliations: | Aggie Research Mentoring Program |
| Project Leader: | Heidi Creed hcreed@tamu.edu Medical Physiology |
| Faculty Mentor: | Joseph Rutkowski, Ph.D. |
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Meeting Times:
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TBA |
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Team Size:
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3
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| Open Spots: | 0 |
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Special Opportunities:
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With significant contributions would receive co-authorship on publications derived from the research.
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Team Needs:
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Ability to contribute 6-8hrs per week. Receive animal handling training. Basic laboratory skills. Good communication skills. Willingness to learn new techniques and skills. Interest in health related research |
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Description:
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This project aims to understand how renal lymphatic endothelial cells, and how signaling to immune cells in the renal environment, regulates the immune and inflammatory response in Acute Kidney Injury (AKI). AKI occurs in approximately 50% of ICU patients and predisposes a patient to develop chronic conditions such as Chronic Kidney Disease (CKD) and End-Stage Renal Disease (ESRD), conditions which decrease quality of life and may be fatal. Increasingly, research demonstrates that AKI induced injury promotes persistent renal inflammation and fibrosis driving progression to CKD and ESRD. Understanding inflammation resolution in AKI is necessary in order to develop renal targeted therapeutics to prevent chronic inflammatory progression to CKD and ESRD. |