| Affiliations: | Aggie Research Mentoring Program |
| Project Leader: | Aja Coleman coleman123@tamu.edu Microbial Pathogenesis and Immunology |
| Faculty Mentor: | Kristin Patrick, Ph.D. |
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Meeting Times:
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TBA |
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Team Size:
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4 |
| Open Spots: | 0 |
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Special Opportunities:
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Learning new skills |
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Team Needs:
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N/A |
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Description:
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Mycobacterium tuberculosis (Mtb) is one of the most infectious and deadly pathogens in the world. Key to Mtb virulence are Mtb membrane-bound and secreted effector proteins that manipulate the host-pathogen interface to promote Mtb survival. Earlier studies identified roughly 100 putative effector proteins that can be secreted from Mtb, but the molecular mechanisms through which these proteins promote Mtb pathogenesis remain elusive. A growing literature suggests that many intracellular bacterial pathogens secrete effector proteins—dubbed nucleomodulins—that traffic to the host cell nucleus and target complexes involved in chromatin remodeling, histone modification, transcription, and pre-mRNA splicing. Rv1075c has been investigated as a potential nucleomodulin |