| Affiliations: | STEM Research Leadership |
| Project Leader: | Shedreanna Johnson
sjohnson22@tamu.edu Medical Physiology |
| Faculty Mentor: | Mariappan Muthuchamy, Ph.D. |
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Meeting Times:
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TBA |
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Team Size:
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3
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| Open Spots: | 0 |
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Special Opportunities:
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Significant contributors will earn authorship on resulting publications, undergraduate research presentation opportunities, potentially attend local conferences (Bryan/College Station), and will receive hands-on learning in laboratory techniques, including RNA and protein isolation, real-time quantitative PCR, immunofluorescence, and more!
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Team Needs:
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Interested in research and motivated to learn new techniques and skills. Ability to contribute 6-8hrs per week. Receive animal handling training. Basic biology understanding and interest in learning about molecular biology, lymphatic biology, and physiology. |
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Description:
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The project aims to understand how mitochondria in lymphatic muscle cells function and contribute to Duchenne Muscular Dystrophy (DMD). Progressive disability due to Duchenne Muscular Dystrophy (DMD) occurs in 1 of every 5000 males due to the X-linked mutation of the DMD gene. The lack of functional dystrophin results in the immune response remaining activated due to muscular injury during contraction. The lymphatic system plays a crucial role in modulating inflammation at the local tissue. However, we have observed impairments in lymphatic function in DMD pathogenesis. Research demonstrates that mitochondrial dysfunction is an early consequence of DMD individuals. May provide insights into the molecular mechanisms driving lymphatic dysfunction and exploring potential therapeutic targets to alleviate DMD progression. |