Spring 2020 – Predicting Transport Properties in Solid Tumors using General Algebraic Formulas

Experimental approaches to determine the flow of nutrients into tumors and the accumulation of fluid pressure in tumors are limited because they arise from the complex interactions of microvascular filtration into tumors and lymph flow from tumors. Existing mathematical models assume specific parameter values to solve, making results impossible to generalize. Therefore, the present work derived general algebraic formulas for critical tumor variables assuming the standard Starling-Landis and the Drake-Laine equations. This novel approach provides novel insights into how tumor properties can affect the transport of nutrients to the tumor and the high tissue fluid pressure within the tumor.