| Affiliations: | |
| Project Leader: | Dolan, Connor cpdolan@cvm.tamu.edu Veterinary Physiology and Pharmacology |
| Faculty Mentor: | Muneoka, Ken |
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Meeting Times:
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Team Size:
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3 (Team Full) |
| Open Spots: | 0 |
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Special Opportunities:
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Students will be able to earn co-authorship on publications, take research credit, and if desired continue on with our lab and continue studying digit regeneration. |
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Team Needs:
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Description:
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Like the human fingertip, the digit tip of mice possesses a similar ability to regenerate; amputation through the terminal phalanx results in the faithful restoration of the digit tip. This regenerative response is highly reproducible and occurs following digit amputation during fetal, neonatal and adult stages. Digit tip regeneration is a complex process both resembling and diverging from digit development. In the mouse, regeneration of the digit occurs through sequential stages which includes inflammation, histolysis, epidermal closure, blastema formation, and finally redifferentiation into structures which were amputated. Presently, it is unknown if the number or regenerating digit tips effects the overall regeneration process of an individual digit. In this project, students will use micro computed tomography to investigate whether the overall regeneration of a mouse digit tip is effected when other digit tips are concurrently undergoing regeneration. |