| Affiliations: |
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| Project Leader: | Faith Olson faitholson99@tamu.edu Biomedical Sciences |
| Faculty Mentor: |
Dr. Christopher M. Quick, Ph.D.
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Meeting Times:
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Thursday 3:55-5:10 *Other times TBD |
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Team Size:
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4 (Team Full)
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| Open Spots: | 0 |
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Special Opportunities:
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Potential opportunity for co-authorship for in manuscript. In addition, presenting work at Student Research Week. 3 491 credit hours
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Team Needs:
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Someone is understanding analytical writing and reading. Has a strong suit in mathematical work and can work with Mathematica. Preferred that you have an interest in this study of research, and have the time required to devote each week.
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Description:
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The damage from hemorrhagic strokes, especially arising from rupture of cerebral aneurysms, arteriovenous or cavernous malformations, can occur within minutes. Cerebral blood flow and intracranial pressure are critical variables that impact clinical outcomes. These variables emerge from the complex interaction of the mechanical properties of the cerebral vasculature, cerebrospinal fluid, brain tissue, and hematoma. Conventional animal models used to study hemorrhagic strokes are inherently limited because hematoma volume is too difficult to control experimentally and results do not readily translate to humans. Although complex computational models can provide key insights absent from animal models, results depend on specific parameter values assumed and cannot be easily extrapolated to different cases. Therefore, the purpose of the present work is to develop a general algebraic formula that predicts cerebral flow and intracranial pressure from critical parameters. Through this algebraic model multiple parameters can be tested simultaneously in order to determine the cause and effect of changing said parameters to cerebral blood flow and intracranial pressure.With the development of this model, outcomes and sensitive parameters can be more readily identified
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