| Affiliations: | |
| Project Leader: | Zane Hayden zane3411@tamu.edu Biomedical Sciences |
| Faculty Mentor: | Dr. Christopher Quick, Ph.D. |
|
Meeting Times:
|
MWF 9:10-10:00 |
|
Team Size:
|
4 (Team Full) |
| Open Spots: | 0 |
|
Special Opportunities:
|
|
|
Team Needs:
|
|
|
Description:
|
The primary determinants of glomerular filtration rate (GFR) are difficult to identify from conventional experimental models. GFR arises from the complex interactions amongst afferent and efferent arterioles, glomerulus, proximal tubule, and peritubular capillaries. While complex computational renal models have provided insights, their results only apply to the very specific set of parameters assumed. It was recently demonstrated that a simplified lumped tubular reabsorption model can yield a general algebraic formula for tubular reabsorption in terms of physical properties of the proximal tubule and peritubular capillaries. Therefore, the purpose of the present work is to extend this simple tubular reabsorption model to develop a general algebraic formula for glomerular filtration in terms of critical physical properties. This model has the potential to identify critical determinants of urin production rates and blood pressure in normal physiology and in various disease states. |