| Affiliations: |
Biomedical Research Certificate Program
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| Project Leader: | Vanessa Liu vanessaliu@tamu.edu Biomedical Sciences |
| Faculty Mentor: | Dr. Christopher Quick, Ph.D. |
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Meeting Times:
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MWF 1:50-2:40pm
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Team Size:
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4 (Team Full)
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| Open Spots: | 0 |
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Special Opportunities:
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Team members will gain research experience on scientific reading and writing, earn research credit, and potential co-authorship on paper. The project will possibly continue into the spring semester and team members could potentially present in conferences and obtain letters of recommendation.
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Team Needs:
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We are looking for dedicated, hardworking BIMS and Biomedical Engineering students who have strong writing and math abilities and are interested in biomedical research. Matlab experience is preferred but not required.
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Description:
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The mechanisms impacting chronic adaptation of cardiac ventricles are difficult to identify, because diastolic volume is both the cause and effect of ventricular wall stress. Diastolic volume affects the ability of the ventricle to pump blood out of the venous system, thus impacting diastolic pressure and wall stress. Conversely, chronic changes in filling pressure affect ventricular wall stress, leading to growth and remodeling that alters diastolic volume. To characterize this interaction of biomechanics and mechanobiology, investigators typically employ sophisticated numerical methods to solve complex mathematical models. Because it is necessary to assume a large number of parameter values pertaining to a particular physiological state, the results lack generality. Therefore, the purpose of the present work is to develop a general algebraic formula that predicts diastolic volume and wall stress in terms of mechanical properties of the cardiovascular system.
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