| Affiliations: | Genetics & Genomics Research Leadership |
| Project Leader: | Joe Romanowski joeromanowski@tamu.edu Genetics & Genomics Research Leadership |
| Faculty Mentor: | Zachary Adelman, Ph.D |
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Meeting Times:
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TBD |
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Team Size:
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3 |
| Open Spots: | 0 |
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Special Opportunities:
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Team Needs:
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Students applying should have a basic understanding of basic genetics concepts and be able to work as a team member |
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Description:
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The Aedes aegypti mosquito is estimated to be responsible for over 400 million dengue infections each year and its global presence poses a public health threat to nearly half of the world. Genetic approaches to reduce disease incidence by suppressing or modifying Aedes aegypti populations have been proposed as a solution, but the persistence of these modifications in nature and how to remove them remain uncertain. Our lab has shown that by triggering a DNA repair pathway known as single-strand annealing (SSA), it is possible to delete these transgenes and revert transgenic mosquitoes back to wild type. This project focuses on understanding how DNA-damaging enzymes and the site of DNA damage influences SSA repair to optimize self-eliminating transgenes. Students working on this project will learn molecular cloning, mosquito rearing and transgenesis, and fluorescent microscopy. Preference will be given to students able to remain for the summer, though it is not required. |