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Spring 2020 – Skeletal Stem Cells in Mouse Digit Regeneration

Affiliations:
DeBakey Executive Leadership Program
Project Leader: Dr. Regina Brunauer
RBRUNAUER@CVM.TAMU.EDU
Veterinary Physiology & Pharmacology
Faculty Mentor:
Meeting Times:
Team Size:
4 (Team Full)
Open Spots: 0
Special Opportunities:
wet lab experience
Description:
Adult stem cells lose their regenerative power with aging. For the progenitors of bone, cartilage and adipose tissue, the skeletal stem cell (aka mesenchymal stem cell), functional changes with aging are unclear, because standardized surface markers have not been available until recently, and transplantation studies equivalent to hematopoietic repopulation are not feasible. The mouse digit tip has been shown to regenerate thanks to recruitment of lineage-restricted progenitor cells, likely including skeletal stem cells. Recently, populations of skeletal stem cells with slightly different features have been identified based on the expression of different surface proteins. In this project, we will perform immunohistochemical stainings for these different subpopulations and track their contribution to mouse digit tip regeneration, a mammalian equivalent to salamander limb regeneration.

Written by:
Jennie Lamb
Published on:
February 18, 2020

Categories: FullTags: Spring 2020

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