• Skip to primary navigation
  • Skip to main content

Aggie Research Programs

Texas A&M University

  • Research Leadership
  • Undergraduates
  • Project List
  • Team Leader Resources
  • Contacts
  • Calendar
  • FAQs
  • Show Search
Hide Search

Spring 2017 – Effect of low-dose ionizing radiation on lymphatic endothelial cells

Affiliations:
Project Leader: Harlan, Collin
cjh5801@tamu.edu
RHEN/NUEN
Faculty Mentor: Ranjeet Dongaonkar, Ph.D.
Meeting Times:
T/TR 11:300 AM – 2:30 PM
Team Size:
1 (Team Full)
Open Spots: 0
Special Opportunities:
Skills learned/developed: How to use an Olympus inverted microscope, how to use MetaFlour Fluorescence Imaging Software, how to handle cultured rat lymphatic endothelial cells, how to handle and use drugs/soultions such as Trypan Blue, Trypsin, Accumax, DMSO, DAF and Fura 2 AM, how to conduct cell viability studies, how to conduct intercellular calcium and nitric oxide studies
Team Needs:
Radiological Health Engineering/Biomedical Engineering/Computer Engineering, Biomedical Sciences MATLAB experience, Microscope handling, Research paper writing/editing
Description:
Lymphatic vessels periodically contract and relax to actively pump lymph, transport immune cells, and are critical for organ health. Lymphatic endothelial cells (LECs) regulate pump function by releasing vasoactive factors, nitric oxide (NO) and prostaglandins, in response to altered lymph flow and composition. It is understood that enhanced LEC NO production induces lymphatic pump failure and leads to organ dysfunction. Although recent radiation studies have reported loss of lymphatic function regarding high-dose radiation, effects of low-dose ionizing radiation on LECs have yet to be investigated thoroughly. Therefore, the goal of these studies to investigate the mechanisms by which low-dose ionizing radiation induces LEC dysfunction. Findings from these studies are expected to form the basis for the development of novel therapeutic strategies to treat organ dysfunction in radiotherapy patients.

Written by:
Jennie Lamb
Published on:
February 4, 2020

Categories: FullTags: Spring 2017

Footer

Texas A&M University  |  Web Accessibility  |  Site Policies  |  Site Support

© 2021, Website by CVMBS Communications, Texas A&M College of Veterinary Medicine & Biomedical Sciences