| Affiliations: |
Biomedical Research Certificate
|
| Project Leader: | Oula Eldow oeldow@tamu.edu Biomedical Sciences |
| Faculty Mentor: |
Dr. Christopher Quick , Ph.D.
|
|
Meeting Times:
|
Wednesday: (1:45 pm – 2:50 pm VIDI 109) (3:00 pm – 6:00 pm in lab)/ Monday: (1:50 pm -3:50 pm in lab)/ Other meeting times as necessary (TBD) |
|
Team Size:
|
4 (Team Full)
|
| Open Spots: | 0 |
|
Special Opportunities:
|
|
|
Team Needs:
|
Register for 291/491 for 3 credit hours (required). Attend the confirmed weekly meeting time; there will be other meeting times by need base. Be passionate about research, particularly biomedical research. Good editing skills and reading skills. If interested, contact team leader no later than June 1st.
|
|
Description:
|
The effectiveness of radiation therapy to treat malignant tumors depends in part on its effect on lymphatic vessels in and adjacent to the tumor. Although high-dose ionizing radiation is known to obliterate lymphatic vessels and inhibit subsequent lymphangiogenesis in vivo, the effects of low-dose radiation is poorly established. The purpose of our research is to utilize the chicken Chorioallantoic Membrane (CAM) model as a platform to evaluate the effect of low-dose radiation on growth and remodeling lymphatic micro-vessels. We have been able to identify. The CAM allows for the measurement of the same blood vessels before and after radiation, and is constantly undergoing lymphatic growth because of continuous increase in flow. We are currently working on solving some challenges with the CAM model, such as keeping temperature constant, maintaining viability ex ovo, and visualizing the vessels. We will then be radiating specimens and quantifying changes in lymphatic function. This is an early-stage project that has potential to expand in scope over several semesters based on interests of participants |